Can you actually do MORE damage than good to your skin by using a lot of anti-wrinkle cream/s? If so, how?

Can you actually do MORE damage than good to your skin by OD-ing on anti-wrinkle creams? If so, how?Can you actually do MORE damage than good to your skin by using a lot of anti-wrinkle cream/s? If so, how?
I've experimented with anti-wrinkle products. None of the ones I tried have made any difference, except for giving me eczema on the nose. You could use a little egg white to tighten the wrinkles but then you could have an allergic reaction. I know you can use natural things like cucumber slices, strawberries, lemons, etc. Best to buy a book on beauty so you can make your own skin treats.